Impact of gender on aminoglycoside induced nephrotoxicity is still controversial and inconclusive. Nov 21, 2016 gentamicin sulfate, a watersoluble antibiotic of the aminoglycoside group, is derived by the growth of micromonospora purpurea, an actinomycete. Antibiotics are a widespread class of drugs and the principal cause of drugassociated nephropathy. Effect of saireito on gentamicin nephrotoxicity in rats. The plant extract of rhazya stricta has been noted to dosedependently increase the superoxide dismutase activity and the reducedform of glutathione and subsequently decrease lipid peroxides in the renal cortex of gentamicin administered rats.
Effect of superoxide dismutase treatment on gentamicin nephrotoxicity in rats. Pathophysiologic mechanisms of selected types of nephrotoxicity. Doses of chrysin 20 and 40 mg kgg1 were selected on the basis of the previous study carried out in this laboratory26. A biochemical and histopathologic study showing protection. Protective role of hydroalcoholic extract of ficus carica. Gentamicin and vitamin c have been proposed as nephrotoxic and antioxidant, respectively. In patients receiving gentamicin for 3 to 5 days, nephrotoxicity occurs in 10% to 25% of the cases. However, gentamicin administration is limited because of nephrotoxicity. Toxicological effects of the iodinated xray contrast media ioversol and potential usefulness for toxicological evaluation of iodinated xray contrast media. Moreover, oxidative stress plays an important role in gentamicin.
Effect of chrysin on gentamicininduced nephrotoxicity in. Protective effect of bauhinia purpurea on gentamicin induced. Attenuation of gentamicininduced nephrotoxicity in rats by fleroxacin article pdf available in antimicrobial agents and chemotherapy 416. Nephrotoxicity is a serious side effect of gentamicin and is believed. Pdf beneficial effects of calcium oral coadministration. This study involved biochemical and histopathologic investigation showing protection and treatment of gentamicin induced nephrotoxicity in rabbits using vitamin c for 26 days hypothesizing that whether vitamin c would inhibit or decrease the raised serum urea and creatinine levels. Modification of biochemical parameters of gentamicin nephrotoxicity by coenzyme q10 and green tea in rats article pdf available in indian journal of experimental biology 445. Salicylic acid attenuates gentamicininduced nephrotoxicity.
Pdf protective effect of quercetin against gentamicin. Gentamicin is a hydrophilic cationic compound that does not readily penetrate cell membranes 7. Inhibitory effect of olive leaf extract on gentamicin. Costus afer ker gawl leaves against gentamicininduced. Gentamicin and streptomycin are the most common antibiotics in group of aminoglycosides. Aminoglycoside antibiotics, in particular gentamicin and tobramycin, are still commonly used in paediatric clinical practice. Request pdf influence of spironolactone treatment on gentamicininduced nephrotoxicity in rats the effect of treatment of rats with gentamicin 80 mgkgday for 6 days, oral doses of. The presented data suggest that astaxanthin has a significant prophylactic action against gentamicin induced nephrotoxicity in rats. Influence of spironolactone treatment on gentamicin. We studied gentamicin susceptibility of kidneys infected with e.
This article is from iranian journal of basic medical sciences, volume 16. Gentamicin, at doses of 50 or 100 mgkg body wt administered daily to healthy male mf1 mice by i. In this forum, i will summarize the renal handling of the aminoglycosides, the pathogenetic mechanisms of nephro toxicity, and the clinical aspects of aminoglycoside induced acute renal failure. Diagnosis and treatment aminoglycoside nephrotoxicity typically is associated with nonoliguric acute renal failure, that is, azotemia in the presence. Antimicrobials are one of the most common classes of medications prescribed globally and also among the most common causes of nephrotoxicity. Subsequently, it was established that aminoglycoside uptake involves absorptive endocytosis. Original article, report by advances in environmental biology. Comparative study on gentamicin and streptomycin induced. The histological examinations of renal tissues in this study revealed damage and glomerular infiltration in gentamicin treated rats.
Nephrotoxicity due to a aminoglycosides b cyclophosphamide c cisplatin d. Administration of the husk extract 187748 mgkg caused significant p nephrotoxicity in rats. Mar 31, 2015 molecular mechanism of drug induced nephrotoxicity 1. Dec 27, 2019 aminoglycosides preferentially affect the proximal tubular cells. Effects of cisplatininduced nephrotoxicity on gentamicin.
Effect of normobaric hyperoxia on gentamicininduced. Effect of cephalothin on renal cortical concentrations of. The objective of the present study is to assess the effect of same s adenosyl methionine a precursor of glutathione endogenous antioxidant in gentamicin induced nephrotoxicity in rats, by measuring serum urea. Hyperbaric oxygen treatment and nephrotoxicity induced by. Beneficial effects of calcium oral coadministration in gentamicin induced nephrotoxicity in rats. Gentamicin gm induced nephrotoxicity may be sex hormones related.
A study comparing renal accumulation in filtering and nonfiltering kidneys demonstrated that gentamicin uptake proceeded via reabsorption across the luminal membrane of the proximal tubular cell18. Gentamicin induced nephrotoxicity in rodents is a well documented model for acute renal failure and provides an opportunity to test different compounds or extracts which could have renoprotective properties. To evaluate the nephroprotective effect of trichosanthes dioica roxb. In this study, it was aimed to investigate the possible protective effect of an ethanolic extract of basella alba l. Nephrotoxicity of cephalosporingentamicin combinations in. The present study was designed to determine whether flavocoxid has a protective effect against gentamicin induced nephrotoxicity in rats. The nephroprotective potential of nrkft was also compared with ethanolic extract of boerhaavia diffusa family. Effect of morin against gentamicininduced nephrotoxicity in. Gentamicin injection is a sterile, nonpyrogenic aqueous solution for parenteral administration.
Inhibitory effect of olive leaf extract on gentamicininduced. These agents are freely filtered by the glomeruli and quickly taken up by the proximal tubular epithelial cells, where they are incorporated into lysosomes after first interacting with phospholipids on the brush border membranes. A modified model of gentamicin induced renal failure in rats. Olive leaf extract ole has been demonstrated to have antioxidant and antiinflammatory. Hook department of pharmacology, michigan state university, east lansing, michigan 48824 received september 12, 1977. The effect of fleroxacin on gentamicininduced nephrotoxicity was evaluated. Gentamicin sulphate nephrotoxicity seems to be attributed to the generation of reactive oxygen species. Several parameters of renal function, histological changes on light and electron microscopy, and drug levels in renal parenchyma were compared in pyelonephritic and normal rats.
Protective effect of apocynin against gentamicininduced. Morin, a bioflavonoid with antioxidant properties, is a constituent of many herbs and fruits that are used as herbal medicines. Effect of apo on gntinduced change in kidney function in rats. The current study aimed to explore the antioxidant and protective effects of pimpinella anisum p. In conclusion, the present study indicates a very important role of reactive oxygen species ros and the relation to renal dysfunction and point to the therapeutic potential of spirulina platensis in gentamicin sulphate induced. Pdf protective effect of crocin on gentamicininduced. Influence of iron, deferoxamine and ascorbic acid on gentamicin induced nephrotoxicity in rats. We performed a retrospective observational study to examine this and the predictive value of rifle stage on patient outcome in this setting. Cimetidine appears to have protective effect on gentamicin losartan induced nephrotoxicity in rats. Assessment of gentamicininduced nephrotoxicity in rats. In rats treated with cephaloridine, gentamicin or leupeptin, disruption of lysosomal membrane was noted and regional cytoplasmic destructionwas seen in the vicinity of the disrupted heterolysosomes. For this purpose, we quantitatively evaluated gentamicin induced renal structural and functional. Aug 15, 2015 gentamicin is a widely used antibiotic against serious and lifethreatening infections. Borade department of pharmacology, rajgad dnyanpeeths college of pharmacy, bhor, m.
Nyctaginaceae, which is a vital constituent of nrkft and also individually used in renal disorders, to elucidate the synergism or additive effect. Administration of the husk extract 187748 mgkg caused significant p gentamicin induced renal failure in rats. Nephrotoxicity can be defined as the adverse effect of substances on renal function perazella, 2009. These cytosomes displaying acid phosphatase activity were demonstrated histo. Although the exact mechanism of gentamicininduced nephrotoxicity is not well. Costus afer ker gawl leaves against gentamicin induced nephrotoxicity in rats anthonet ndidi ezejiofor,1 chinna nneka orish,2 orish ebere orisakwe1 introduction. Gentamicin nephrotoxicity in diabetic old rats induced mortality in about a third of the animals used, whereas no mortality was seen in young diabetic rats treated with gentamicin. As the use of aminoglycosides became more widespread, the toxic effects of these agents, most notably ototoxicity and nephrotoxicity, became more apparent. In the toxic group, rats were administered gm only 100 mgkg, i. Inhibitory effect of olive leaf extract on gentamicin induced nephrotoxicity in rats majid tavafi, 1 hasan ahmadvand, 2 pooran toolabi 3 introduction. The aim of the present study was to evaluate the protective effect of crocin against gentamicininduced nephrotoxicity in rats. This effect may be responsible, in part, for the reduction in nephrotoxicity reported previously in animals given the combination of drugs. The objective of this study was to evaluate the effects of daptomycin and vancomycin on tobramycininduced nephrotoxicity. Pdf modification of biochemical parameters of gentamicin.
One of the complications of gentamicin and streptomycin is nephrotoxicity. The effects of two nonsteroidal antiinflammatory drugs, ibuprofen 20 mg day. Nephroprotective activity of husk extract of zea mays. Gentamicin gm is one of the commonest causes of drug. A single dose of gentamicin 30 mgkg, iv was given to different groups of rats alone, at the same time as, or on day 4, 7, 15, or 29 following cisplatin administration 6 mgkg, iv. Pdf in this study, we aimed to investigate the possible protective effect of resveratrol on gentamicin induced nephrotoxicity. Effect of morin against gentamicin induced nephrotoxicity in young male rats hala a. Schwartz pathologytoxicology department, scheringplough corporation, lafayette, new jersey 07848. Pdf gentamicininduced nephrotoxicity in rats ameliorated and. Phlorizininduced glycosuria does not prevent gentamicin. Pdf gentamicin induced nephrotoxicity in albino mice.
Comparative toxicity of gentamicin and tobramycin in rats. Ethanolic extract of garlic for attenuation of gentamicin. Functional nephrotoxicity of gentamicin in the rat. Effects of cosupplementation of vitamins e and c on. Gentamicininduced apoptosis in renal cell lines and embryonic rat.
Protective effect of quercetin against gentamicininduced nephrotoxicity in rats. A number of crude herbal extracts have been reported to ameliorate gentamicin induced nephrotoxicity. Effects of bss on gentamicin nephrotoxicity in rats gentamicin administration caused kidney injury in rats, as indicated by significant increases in blood urea nitrogen bun and blood creatinine levels by 3 and 2fold, respectively, when compared with the non gentamicin. Dailymed gentamicin gentamicin sulfate injection, solution. Finally, gentamicin nephrotoxicity is potentiated by magnesium depletion 27. Toxicology and applied pharmacology 63, 194200 1982 comparative toxicity of gentamicin and tobramycin in rats at low multiples of the human therapeutic dose g.
The effects of cisplatin induced nephrotoxicity on the pharmacokinetics of a renally excreted antibiotic, gentamicin, were studied in f344 rats. India abstract gentamicin gm induced nephrotoxicity limits its longterm clinical use. Effect of dimethyl sulfoxide on gentamicin induced nephrotoxicity in rats. Female spraguedawley rats were treated during 4 and 10 days with either saline nacl. The interaction between gentamicin and other nephrotoxic drugs such as. In this study we investigated the role of free radicals in gentamicin. Research article gentamicin induced nephrotoxicity. Pomegranate extract attenuates gentamicin induced nephrotoxicity in rats by reducing oxidative stress mustafa cekmen1, alper otunctemur2, emin ozbek2, suleyman sami cakir2, murat dursun2, emre can polat3, adnan somay4 and nurver ozbay4 1departmentofbiochemistry,kocaeliuniversity,kocaeli,turkey. Increased nephrotoxicity of gentamicin in pyelonephritic rats. Aminoglycosides are concentrationdependent, bactericidal agents that undergo active transport into the cell where they inhibit protein synthesis on the 30s subunit of the bacterial ribosome. Inhibitory effects of cinnamon extract on gentamicin induced nephrotoxicity in mail adult wistar rats.
A modified model of gentamicin induced renal failure in. The effect of saireito, an oriental traditional medicine, against gentamicin nephrotoxicity was examined in gentamicin nephrotoxicity rat models. Gentamicin, cimetidine, losartan, vitamin e, rats, nephrotoxicity. In vivo, approximately 90% of a gentamicin dose is recovered in the urine8. Gentamicininduced nephrotoxicity in rats ameliorated and healing. Renal cortical concentrations of gentamicin were significantly lower in rats given this aminoglycoside and cephalothin simultaneously than in animals given gentamicin alone. To study the possibility that cephalosporins augment the nephrotoxicity of gentamicin, groups of rats were given four hourly subcutaneous doses of. Introduction gentamicin is an aminoglycoside antibiotic widely used for the treatment of bacterial infections. Aminoglycosides have long been one of the commonest causes of drug induced nephrotoxicity. The role of sex hormones in gonadectomized male and female rats fatemeheshraghijazi, 1 ardeshirtalebi, 1,2 fatemehsadatmirsaeedi, 1 sarinaahmadian, 1 fatemehmoslemi, 1 andmehdinematbakhsh 1,3,4 water and electrolytes research center, isfahan university of medical sciences, isfahan, iran. For this purpose female spraguedawley rats were given intraperitoneally either gentamicin sulphate 40 mgkg, melatonin 10 mgkg, gentamicin plus melatonin or vehicle control twice. Flavocoxid attenuates gentamicininduced nephrotoxicity in rats.
Gentamicininduced nephrotoxicity in rats ameliorated and healing effects of resveratrol. These substances can include molds and fungi, cancer therapeutics such as cisplatin, antibiotics such as aminoglycosides, metals such as mercury, arsenic and lead, and drugs of abuse such as cocaine. Multiple factors may increase the nephrotoxic potential of aminoglycosides. Gentamicin nephrotoxicity is a common clinical situation in patients who receive it for a longer time period. Furthermore, these biochemical observations were supplemented by histological examination of the rat kidneys. Nephrotoxicity was induced in rats except normal by gm at a dose of 120 mg kgg1, i. Despite significant research in this field, the molecular mechanism associated with gentamicin nephrotoxicity is not completely understood. Assays of kidney function parameters as well as histopathological study of the kidney were used to assess nephroprotective activity of husk extract. Ethanolic extract of garlic for attenuation of gentamicin induced nephrotoxicity in wistar rats hamid nasri,1 mehdi nematbakhsh,1 mahmoud rafieiankopaei2 introduction. Pdf histopathological evaluation of nephroprotective. However, due to its side effects, there are some limitations in the use of gentamicin and streptomycin.
Attenuation of gentamicininduced nephrotoxicity in rats by. Although a clear recognition of the patient and treatmentrelated risk factors, combined with the onceaday schedule and effective monitoring procedures, have definitely improved the situation over what prevailed in the early 1980s, we are still short of having brought the safety of. Pdf hesperidin protects gentamicininduced nephrotoxicity via nrf2ho1 signaling and inhibits inflammation mediated by nf. Cox inhibition and gentamicin nephrotoxicity brazilian journal of medical and biological research 2004 37. Environmental issues aminoglycosides antioxidants antioxidants nutrients cinnamon health aspects laboratory rats materia medica, vegetable plant extracts rats as laboratory animals toxicity research urea.
Phenolic extract of soybean glycine max attenuates. Nephrotoxicity is a significant adverse side effect of gentamicin. Aminoglycosideinduced nephrotoxicity in children pdf. Nephrotoxicity induced by aminoglycosides manifests clinically as nonoliguric renal failure, with a slow rise in serum creatinine and a hypoosmolar urinary output developing after several days of treatment. In old rats, diabetes had significantly less protective effect on the gentamicin induced nephrotoxic signs than in the young rats. Inhibitory effects of cinnamon extract on gentamicininduced. Does propylthiouracil increase the gentamicininduced. The incidence of gentamicin associated acute kidney injury aki as defined by the rifle criteria is unknown. Protective effect of crocin on gentamicininduced nephrotoxicity in rats. Their nephrotoxic response to gentamicin was compared to that of nonglycosuric. Reduction of experimental gentamicin nephrotoxicity in rats.
A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the. Gentamicin gm is a widely used antibiotic against serious and lifethreatening infections, but its usefulness is limited by the development of nephrotoxicity. Gender differences in aminoglycoside induced nephrotoxicity. Rats of groups 2, 3, and 4 were pretreated orally for 4 days with curcumin 200 mgkgday, ginkgo biloba leaf extract 300 mgkgday, and a combination of curcumin and ginkgo biloba leaf extract, respectively before concomitant administration of gent for additional 6 days. The aim of this study was to evaluate the effect of subacute.
Effect of cimetidine on gentamicinlosartan induced. Subacute administration of crude khat catha edulis f. Aminoglycoside nephrotoxicity kidney international. Effects of daptomycin and vancomycin on tobramycin.
Mechanisms of antimicrobialinduced nephrotoxicity in. The objective of this study was to investigate the nephrotoxic potential of amikacin ak and gentamicin gm in male and female. Effect of cyclooxygenase inhibitors on gentamicininduced. Phenolic extract of soybean glycine max attenuates cisplatin induced nephrotoxicity in rats author links open overlay panel martins ekor godwin o. The effects of sex hormones on gm induced nephrotoxicity in gonadectomized rats were investigated.
Effect of methanolic extract of hibiscus plantinifolius leaves on serum and urine electrolytes in gentamicin induced nephrotoxicity. Effect of normobaric hyperoxia on gentamicin induced nephrotoxicity in rats. Rats subjected to gentamicin induced nephrotoxicity, treated with pioglitazone at dose of 0. Cardiotrophin1 therapy prevents gentamicininduced nephrotoxicity in rats author links open overlay panel yaremi quiros a victor blancogozalo a jose i. These drugs cause nephrotoxicity, which particularly affects the proximal tubule epithelial cells due to selective endocytosis and accumulation of aminoglycosides via the multiligand receptor megalin.